Purpose- Key purpose of the study is to analyze the correlation between E-commerce and Drivers of Supply Chain Management to facilitate the Entrepreneurship Business in Tanzania, East Africa. Study Locale is the Chief Information Officers of the corporation of Tanzanian, e-commerce based Small and Medium sized Entrepreneurship business. Study tends to highlight the impact of E-commerce on SCM drivers: Procurement, Merchandise Management, Store Location, Transportation and Information Methodology/Design- For the just cause, study uses the quantitative approach, self made questionnaire based design for the investigation of affects of E-commerce on SCM drivers. Causal relationship methods are adopted for the analysis based on IBM SPSS. Statistical Treatment- Tools used for the analysis of the causal relationship variables are Biserial and Pearson correlation and linear regression for the analyzing the level of impacts of independent variable on dependant variable. ANOVA is used for the degree changed in Variance, T-test and Kurtosis is used for the hypotheses testing. Descriptive statistics will be used for interpretation of the 5 likert scale questionnaire. Results- Expected results are highlighted as the key drivers of the SCM such as: Procurement, Merchandise Management, Store Location, Transportation and information are correlated with E-commerce and have positive relationship. Originality/Values- Research is based on first hand data collection through 5 likert scale questionnaire, providing expert point of view on the subject, presents originality and valuable contribution for the Entrepreneurs of Tanzania.