Weeds represent a significant challenge to successful crop production. Highly effective and sustainable weed control is required in order to meet global food demand. In this context, excessive use of herbicides has resulted in serious environmental and ecological issues. There are several weed control options which neither harm the environment nor require a significant increase in cost of production. Improving crop competition is particularly important and attractive among such options, which can be achieved by using crop cultivars possessing a competitive advantage over weeds, and manipulating the seed rate and direction of crop rows. Crop cultivars possessing traits such as fast germination, quick growth, high biomass, and large leaf area have a competitive advantage over weeds. Sowing such cultivars has been shown to suppress weeds in various crops. The use of high seed rates and narrow row spacing, if properly manipulated, can cause a significant decrease in weed proliferation in the crops. These techniques (cultivar, seed rate, row spacing, and row direction) are under-exploited as weed control methods, and offer considerable potential for achieving environmentally benign weed management. This special issue on “Eco-friendly Weed Management” will address the role of crop competition in managing weeds in different crops as well as in different countries.