With the aim of promoting biological, social and psychological well-being, a multi-institutional and multidisciplinary action-research process was developed for the regeneration of a large residential complex in Rome, Italy. A methodology with a community-based approach was adopted in a context where spatial segregation is intertwined with health and social inequalities. Methods: Through qualitative-quantitative analysis involving the active participation of the local population and institutions in every stage, an integrated survey model was developed in order to create proper communication between the needs of the population and sustainable solutions. Results: the implemented process allowed for clear planning of actions and interventions that could be economically sustainable through the structuring and development of a local network. Conclusions: the process involving the participation of the population in the analysis of their own problems and difficulties, as well as in the development of possible interventions and actions to be proposed, appears to be the only adequate approach that allows for the definition of mutual objectives based on the real needs of the end users.