The set of methodologies of lean management defines the management system in series production. The transformation and adaptation of these methodologies towards higher complexity, higher variants and changeable manufacturing aim at activating productivity potential in series and small batch production. Lean management methodologies, which have been successfully implemented in automotive and supplier industries, are quasi standards of today’s efficient manufacturing. The competitiveness under the European conditions of high wages and changing markets and technologies revealed that lean management is a prerequisite but cannot reach the cost advantages in general. Lean management methodologies are required for customised manufacturing. 1.1.1 Preventive Quality Management The quality and reliability of products, services and industrial operations (business processes) are preconditions for High-Adding-Values and the growth of demanding manufacturing sectors. Following the trends towards customised products and build to order strategies in manufacturing, new and efficient methods are required in all manufacturing sectors, in order to assure quality and reliability in early phases of products. Preventive quality management approaches are required. They include innovative methodologies for the introduction and management of the life cycle of new generations of products, such as those including mechatronics and intelligent products. There should be a focus on the design of quality and reliability and the design process should include the ability to forecast the utilisation and life time of complex products. Methodologies have to take into account the development of products by co-operative and networked engineering, the capability of the design, manufacturing and measurement processes and the influences of manufacturing technology choices.