This study aims to investigate individual behavior towards adoption of telemedicine application based on wireless sensor network applications (WSN) during COVID-19 pandemic. Therefore, the research model extends the unified theory of acceptance and use of technology with the task technology fit model, awareness and self-efficacy to determine user intention to adopt wireless sensor network application for medical assistance. A research survey was conducted towards Saudi citizens in voluntary setting. In response, 348 valid responses were retrieved. Sample size was computed with prior-power analysis using G-power software. The research model is empirically tested with latest statistical approach namely structural equation modeling (SEM). Findings of the structural model indicate that wireless sensor network application was jointly predicted by performance expectancy, social influence, effort expectancy, facilitating condition, task technology fit, awareness and self-efficacy and explained substantial variance R2 79.5% in individual behavior to adopt wireless sensor network application. The effect size analysis (f 2) revealed that task technology fit and facilitating condition were the most important factors to determine user intention to adopt wireless sensor network application. The current study contributes to theory by extending the unified theory of acceptance and use of technology with task technology fit model, selfefficacy and awareness and enrich information system literature in the context of user intention to adopt wireless sensor network application. Practically, this study suggest that health consultant should focus on technology fitness including wireless devices and the number of facilities to operate wireless sensor network which in turn boost user confidence towards adoption of wireless sensor network application for health consultation. This study develops a unique research model that inspects user behavior towards adoption of wireless sensor network technology for better health care system. The findings of this study answer how to monitor COVID-19 while using of wireless sensor network applications. Moreover, this study is useful for clinical management through virtual environment and guides health advisors, software developers and physicians to design user friendly telemedicine application by using wireless sensor network technology.