Textile wastewater is widely produced and its discharge without treatment contributes to environmental pollution. The adsorption process is a suitable and eco-friendly process due to its low initial cost, no formation of degradation products, operation simplicity, insensitivity to toxic compounds, and the possibility of removal from greatly diluted solutions. Orange seed (OS) powder, from which lipids were removed by hexane extraction, was evaluated as a bio-adsorbent to remove dyes from real textile wastewater. In the screening step, pH was a more significant variable (p-value < 0.05) than bio-adsorbent dosage, temperature, stirring speed, and process time. Moreover, under optimized conditions (pH = 2.6, 0.58 g/L from OS powder and 26 ◦C), more than 95% of the dye was removed from real textile wastewater. Additionally, the dye removal percentage was reduced by only 4% when the volume of textile wastewater was increased from 0.05 L to 10 L. Then, 96% turbidity was removed using a 3 µm tubular ceramic membrane at a pH of 11. Furthermore, the permeate flux through the membrane was kept constant for longer than was observed at low pH (<11). Therefore, the proposed process is an interesting option, due to the fact that orange seeds are currently not valorized and, combined with the membrane process, this could prove a suitable option for the treatment of real textile wastewater.