Globalization has prompted enterprises worldwide to increasingly seek the optimal supply chain configuration. However, outsourcing, shortened product life cycles, and a reduced supply base severely weaken supply chain risk tolerance. With the emergence of blockchain, enterprises see an opportunity to mitigate supply chain risks. The purpose of our research is to explore supply chain managers’ intention to adopt blockchain technology from the perspective of supply chain risk management. Using a survey sample of 203 managers in China and the USA, we explored the impact of four perceived benefits of blockchain technology on supply chain risk resistance by extending the technology acceptance model. The results show that the traceability, transparency, information sharing, and decentralization of blockchain can enhance the perceived usefulness of blockchain in supply chain resilience and responsiveness, and the ability to withstand disruption risks and supply and demand coordination risks encountered in the supply chain, thus promoting the adoption of the technology. In addition, the relationships between supply chain resilience and blockchain technology adoption and between supply chain responsiveness and blockchain technology adoption are more salient for managers with high levels of uncertainty avoidance.