Implanted short-term and long-term medical devices have been exhibiting extreme promises in promoting quality of life while increasing life expectancy of affected individuals. The risk of bacterial infections associated with open surgery or the implementation of these devices remains to be a major drawback. The primary causes of infections associated with medical devices are Staphylococcus epidermidis and Staphylococcus aureus. The two potential interventions to bacterial infections associated with medical devices include the development of materials that could discourage bacterial adherence and exhibit antimicrobial activity. The preventional methods ranged from the development of anti adhesive polymers comprising the implant to impregnating implant cements with antibiotic devices that extend the therapeutic response due to slow release effect. New areas of implant research include the use of liposomal antibiotics as coatings for implants. In this communication, we will review the chemical nature of commonly used implants, the source of infections, as well as the preventional measures of coatings and the antibiotics employed to reduce infection due to different implants and medical devices