The diagnostic reference levels (DRLs) for pediatric brain computed tomography (CT) are provided for groups divided according to age. We investigated the relationships of radiation dose indices (volume CT dose index and dose length product) with age and weight, as continuous variables, in pediatric brain CT. In a retrospective analysis, 980 pediatric brain CT examinations were analyzed. Curve fitting was performed for plots of the CT dose indices versus age and weight, and equations to estimate age- and weight-dependent standard dose indices were derived. Standard dose indices were estimated using the equations, and the errors were calculated. The results showed a biphasic increase in dose indices with increasing age and weight, characterized by a rapid initial and subsequent slow increase. Logarithmic, power, and bilinear functions were well fitted to the plots, allowing estimation of standard dose indices at an arbitrary age or weight. Error analysis suggested that weight was mildly better than age and that the best results were obtained with the bilinear function. Curve fitting of the relationship between CT dose indices and age or weight facilitates the determination of standard dose indices in pediatric brain CT at each facility and is expected to aid the establishment and application of the DRLs.