The purpose of the study was to determine the moderating effect of organizational culture on the relationship between supply chain integration and performance in the manufacturing sector of Kenya. The study employed an explanatory research design. The study used network theory. The target population was 217 procurement managers from 217 food and beverage manufacturing companies. A sample size of 140 respondents was selected. The study employed a simple random sampling technique to choose the sample. The collection of primary data was facilitated by the administration of a questionnaire. The data were subjected to regression analysis for the purpose of analysis. The findings of the study provide confirmation that there is a moderating effect of organizational culture (β1 = 0.224, P < 0.05) on the relationship between supply chain integration and the performance of food manufacturing firms. The research findings indicate that the influence of supply chain integration on the performance of food manufacturing firms is contingent upon the organizational culture. Food and beverage manufacturing businesses should consider enhancing the comprehensiveness of their supply chain integration procedures. This may be achieved by granting suppliers access to their inventory management systems, enabling them to make timely choices on inventory replenishment. The integration of supply chains facilitates the exchange of management practices across enterprises, enhances the management of supplier expertise, and allows suppliers to communicate any difficulties that may impact order fulfillment to the organization.