In the present era, economy is the basis of wealth and power production and is the infrastructure of international relations in any country. Even countries that have weak political and military power are trying to improve their economic status through appropriate international ties. This issue was of interest to the Islamic Republic of Iran and the country conducted a lot of planning to achieve economic development, but economic sanctions were always hard obstacles to achieve this goal. The recent sanctions were imposed by the United States and Europe, affected large part of the economy. However, the intelligent approach of the Supreme Leader in adopting resistance economic strategy, not only did not reduce the growth of country's economy, but led to growth and development of internal economic and promote positive interaction in the international arena. In this article we discuss the role of resistance economy in international law. To achieve this goal, first, a brief review of definitions and the pillars of resistance economy and its consequences are presented. Then the role of resistance economy in internals table condition and in international law will be investigated and challenges in adopting resistance economy from the perspective of international law will be discussed.